In vitamin D intoxication, how is PTH typically affected?

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Study for the Disorders of Calcium and Phosphate Metabolism Test. Utilize flashcards and multiple choice questions, each with hints and explanations. Prepare for your exam!

Multiple Choice

In vitamin D intoxication, how is PTH typically affected?

Explanation:
Hypercalcemia from vitamin D excess triggers a negative feedback response on the parathyroid glands. The elevated calcium level signals the calcium-sensing receptors in the parathyroids to reduce PTH secretion because PTH acts to raise blood calcium. In vitamin D intoxication, calcium is high due to increased intestinal absorption and bone resorption, so the body suppresses PTH. That’s why PTH is typically suppressed in this scenario.

Hypercalcemia from vitamin D excess triggers a negative feedback response on the parathyroid glands. The elevated calcium level signals the calcium-sensing receptors in the parathyroids to reduce PTH secretion because PTH acts to raise blood calcium. In vitamin D intoxication, calcium is high due to increased intestinal absorption and bone resorption, so the body suppresses PTH. That’s why PTH is typically suppressed in this scenario.

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