Is secondary hyperparathyroidism present in PHP Type 1B?

Is secondary hyperparathyroidism present in PHP Type 1B?

• A. Yes
• B. No
• C. Only in infancy
• D. Unknown

Answer: (A)

Pseudohypoparathyroidism involves end-organ resistance to parathyroid hormone, especially in the kidney, which leads to hypocalcemia and hyperphosphatemia. The parathyroid glands respond to the low calcium by increasing PTH secretion. In PHP type 1B, this renal PTH resistance persists even though skeletal features may be absent, so the elevated PTH is a compensatory reaction to the hypocalcemia rather than a primary overproduction. That rise in PTH fits the idea of secondary hyperparathyroidism, driven by the body's attempt to correct low calcium. So, secondary hyperparathyroidism is present in PHP Type 1B.

Pseudohypoparathyroidism involves end-organ resistance to parathyroid hormone, especially in the kidney, which leads to hypocalcemia and hyperphosphatemia. The parathyroid glands respond to the low calcium by increasing PTH secretion. In PHP type 1B, this renal PTH resistance persists even though skeletal features may be absent, so the elevated PTH is a compensatory reaction to the hypocalcemia rather than a primary overproduction. That rise in PTH fits the idea of secondary hyperparathyroidism, driven by the body's attempt to correct low calcium. So, secondary hyperparathyroidism is present in PHP Type 1B.